Causes, Significance and Pathophysiological Rationale of Hyperbilirubinemia

Student’s Name

Institutional Affiliation

Don't use plagiarized sources. Get Your Custom Essay on
Causes, Significance and Pathophysiological Rationale of Hyperbilirubinemia
Just from $13/Page
Order Essay

Causes, Significance and Pathophysiological Rationale of Hyperbilirubinemia

Hyperbilirubinemia or excessive bilirubin is the main cause of jaundice. Bilirubin that is responsible for yellow color in jaundice is a normal pigment that is released from red blood cells breakdown. Jaundice is caused by a problem from any of bilirubin three phases. Before bilirubin is produced, unconjugated jaundice may be present due to increased bilirubin that is caused by hemolytic anemia and reabsorption of a large hematoma (Demet Cabar, Aydin, & Gullu, 2014). During bilirubin production, some jaundice causes include viruses like Chronic Hepatitis B and C, Hepatitis A and Epstein-Barr virus infection. Other causes include, rare genetic metabolic defects, alcohol, autoimmune disorders and medicines like Chlorpromazine, Penicillins, Oral contraceptives, Acetaminophen and Estrogenic or anabolic steroids.

Demet Cabar, Aydin, & Gullu, 2014, Hyperbilirubinemia is found both in adults and children. Jaundice is common in infants because they have high level of blood vessels which breakdown and frequently replaced. The baby’s liver is not fully developed making it less effective in processing bilirubin and discharging it from the blood. Their bilirubin is twice as high as in adults. Hyperbilirubinemia is clinically significance in that it is associated with high mortality especially in babies. The condition also significantly increases the likelihood of common duct stones in clients with acute cholecystitis.

Neonatal physiologic jaundice is as a result of simultaneous occurrence of two phenomenons. Production of bilirubin is elevated due to increased fetal erythrocytes breakdown resulting to shortened fetal erythrocytes lifespan and the higher erythrocyte mass in neonates (Ip, 2003). The excretory heparin capacity is low in concentration due to low binding protein ligandin in hepatocytes and due to the low glucuronyl transferase activity that is responsible for binding bilirubin to glucuronic acid making it water soluble. Bilirubin is an end product of heme produced by in the reticuloendothelial system formed through oxidation-reduction reactions. In the liver, bilirubin is transported in to the liver cells where it bores to ligandin.


Demet Cabar, H., Aydin, A., & Gullu, U. (2014). Care in neonatal jaundice. International Journal Of Academic Research, 6(3), 8-14.

Ip, S. (2003). Management of neonatal hyperbilirubinemia. [Rockville, Md.]: [U.S. Dept. of Health and Human Services, Public Health Service, Agency for Healthcare Research and Quality].

Place your order
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
The price is based on these factors:
Academic level
Number of pages
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more
Live Chat+1(978) 822-0999EmailWhatsApp

Order your essay today and save 20% with the discount code LEMONADE